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20 In this real-world study using data from over 2,400 patients with overweight or obesity and type 2 diabetes, most patients who started a GLP-1 agonist lost weight through 72 weeks and one third lost a clinically meaningful amount (at least 5% of body weight)

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The db/db mouse is a well-established and widely used model of obesity-associated and diabetes-related fatty liver disease It exhibits key pathological features that resemble human diabetic MASLD, including severe insulin resistance, hyperglycemia, hyperlipidemia and hepatic steatosis [32]